The Substance Abuse and Mental Health Services Administration (SAMHSA) is accepting applications for the first-ever SAMHSA Harm Reduction grant program and expects to issue $30 million in grant awards. SAMHSA will distribute $10 million per year over the next three years. Grant recipients must use the funds to support harm reduction services. Harm reduction service providers will be asked to develop or expand evidence-based services that may include, but not be limited to: the provision of sterile syringes, safe sex kits, prevention education about synthetic opioids and other substances, overdose prevention kits including naloxone distribution, peer worker engagement, medical services, case management and referral to treatment. Warm handoffs that facilitate engagement in care and referrals to treatment for individuals seeking these support services are also critical components of this grant program. Harm reduction services will be trauma-informed and guided by harm reduction stakeholder groups and other community members. Applications due February 7, 2022.